Abstract
Background: During cardiopulmonary bypass it is a challenge for the attending anesthesiologist to find the optimal dosage of anesthetics because the commonly used parameters endtidal anesthetic gas concentration or other vital signs indicating depth of anesthesia are not usable. Overdosage of anesthetics may be corelated with impaired outcome (1), while insufficient depth of anesthesia results in intraoperative awareness. Electroencephalographic-based monitoring systems such as the bispectral index (BIS) may reduce anaesthetic overdose rates and ensure sufficient depth of anesthesia. We hypothesized that goal-directed sevoflurane administration (guided by BIS monitoring) could reduce the sevoflurane plasma concentration (SPC) and intraoperative vasopressor doses during on-pump cardiac surgery.
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