Abstract
Bispecific antibodies (BsAb) can, by virtue of combining two binding specificities, improve the selectivity and efficacy of antibody-based treatment of human disease. Antibodies with two distinct binding specificities have great potential for a wide range of clinical applications as targeting agents for in vitro and in vivo immunodiagnosis, therapy and for improving immunoassays. They have shown great promise for targeting cytotoxic effector cells, delivering radionuclides, toxins or cytotoxic drugs to specific targets, particularly tumour cells. The development of BsAb research goes through three main stages: chemical cross linking of murine-derived monoclonal antibody, hybrid hybridomas and engineered BsAb. This article is providing the potential applications of bispecific antibodies.
Highlights
In the first decade of this century Paul Ehrlich proposed the idea of using 'bodies' which possess a particular affinity for a certain organ [1]
The results indicated that bispecific antibodies that recognize both S. aureus 305 capsular polysaccharide and neutrophil antigens potentiate the bactericidal activity of neutrophils
Bispecific monoclonal antibody (BsMAb) is able to activate the immune defense system by artificially combining humoral and cellular components to retarget them to tumors or viral infected cells
Summary
5. Cell fusion is labour-intensive, time consuming, and may not always succeed with the hybridoma pairs of choice. 6. Not all hybridoma cell lines exhibit good fusion performance. 7. Most parental hybridomas are derived from the fusion of HAT-sensitive myeloma fusion partners and immune spleen cells
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