Abstract
ObjectivesThe current study is to estimate the bisoprolol (BOP) oral treatment of rats against the myocardial infarction (MI) administrated by using isoproterenol (ISO). MethodsTreatment of rats are MI administration by subcutaneous for two successive days of ISO (85 mg/kg). The tissue of heart is removed without delay, it is washed used isotonic chilled saline in this study. Plasma is separated from the collected rat blood and further analysis of biochemical parameters were carried out. ResultsGroup of ISO-treated rats have increased levels of glucose in blood, also observed the activity of lipids in plasma along fibres of muscle with hyalinization, compared to BOP treated rats, and ISO + BOP treated rats. The parameter values of BOP administered rat were close to control rats. Reports clearly state that ISO + BOP treated rat tissue of heart damage is reduced when compared to ISO treated rats. ConclusionsRats were treated with ISO + BOP to defend against hyperlipidaemia and tissue of cardiac damage and followed by MI. Hence, to investigate the biochemical and biophysical BOP mechanism against MI risk in rats.
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