Abstract
To evaluate the effect of beta-blocker in diastolic heart failure (DHF), Dahl salt-sensitive rats fed on 8% NaCl diet from age 6 weeks, DHF model rats, were divided into 3 groups at age 13 weeks: rats treated with bisoprolol at 12.5 mg/kg/day (LD-group), those treated with bisoprolol at 250 mg/kg/day (HD-group) and untreated rats (Untreated group). The administration of bisoprolol dose-dependently improved a survival rate of the DHF model rats. LV hypertrophy and expression of proinflammatory cytokines significantly decreased in the HD-group, but not in the LD-group, and the oxidative stress was dose-dependently attenuated.
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