Abstract
It appears that Balzer was the first to suggest bismuth as an antisyphilitic drug in the treatment of human syphilis. Anticipating such an employment of bismuth, Balzer 1 first studied its effects in dogs. Severe untoward reactions consisting notably of stomatitis and enteritis resulted in the animals treated, and Balzer discontinued his studies. In 1916, Sauton and Robert, 2 following the publication of their work on the bactericidal action of bismuth compounds, reported on the spirocheticidal action of bismuth in hen spirillosis due to Spirochaeta gallinarum . The drug they employed was sodium tartrobismuthate. Their anticipated work on the action of bismuth in the treatment of recurrent fever and of syphilis was interrupted by the recent war. Sazerac and Levaditi, in 1921 3 and 1922, 4 reported the results of their experiments on bismuth compounds—bismuth ammonium citrate, lactate, subgallate, oxyiodgallate, and sodium and potassium tartrobismuthate, in the treatment of rabbit syphilis.
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