Abstract
In January, 1922, Levaditi and Sazerac 1 reported a series of observations on the treatment of syphilis by the various bismuth salts. The possible usefulness of bismuth had been suggested to them by an earlier paper of Sauton and Robert 2 on the prophylaxis and treatment of spirochetosis of fowls by bismuth salts. Levaditi and Sazerac's experiments included a series of tests on rabbits for toxicity and spirocheticidal action, and a few observations on the treatment of human syphilis. In their preliminary work, they examined the action of a number of bismuth salts, including the citrate, lactate, subgallate and a quadruple salt referred to as potassium sodium tartarobismuthate. In regard to toxicity, they found in general that the soluble salts were more toxic than the insoluble and far more toxic when injected intravenously than when injected subcutaneously. Of all, the tartarobismuthate was the least toxic. If suspended in oil and
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