Abstract
Hold tight: Bismuth complexes including ranitidine bismuth citrate effectively inhibit the nucleoside triphosphate hydrolase and DNA unwinding activities of the SARS coronavirus (SCV) helicase and dramatically reduce SCV replication levels in infected cells. This suggests that bismuth-based drugs should be further evaluated for the treatment of SCV infections in vivo. ss=single-stranded DNA, ds=duplex DNA. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z701021_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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