Abstract
Based on the sequence of the prototypical chemotactic tripeptide HCOMetLeuPheOH (fMLF) and by taking into account the versatility shown by its N-terminal carbamate analogues, the new biscarbamates MeOCOMetLeugPheCOOMe ( 2) and BocMetLeugPheCOOMe ( 4) were synthesized. These two new ligands are characterized by the presence of a gem-diamino residue (gPhe) replacing the C-terminal Phe and a carbamate functionality positioned at both the ends of the molecule. The activity of the two new compounds has been determined on human neutrophils and compared to that shown by the corresponding N-terminal monocarbamates MeOCOMetLeuPheOMe ( 1) and BocMetLeuPheOMe ( 3).
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