Abstract
ABSTRACTA new Pd(II)-N-heterocyclic carbene (NHC) complex 2 was derived from a binuclear Ag(I)-NHC complex 1. 1H NMR spectra of complexes showed uniquely different characteristic behavior of bridging methylene protons than compared with the ligand. X-ray crystallography showed that palladium at the center of bis-NHC units in 2 was found in square-planar geometry. Ligand and complexes were tested against breast cancer cells (MCF-7). The ligand did not show considerable antiproliferative activity (IC50 181.0 ± 3.0 µM) whereas complexes showed significant activity (1: 0.5 ± 0.1 μM; 2: 2.5 ± 0.2 μM) compared with the standard drug, tamoxifen (2.4 ± 0.2 μM).
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