Bis‐dihydropyrimidines: Catalyst‐free, Microwave‐assisted Organic Synthesis, Characterization and In Vitro Biological Screenings

Abstract

In present research, we aim to afford the catalyst‐free, greener synthesis of diethyl 2,2′‐(1,2‐phenylenebis(methylene))bis(sulfanediyl)bis(6‐methyl‐4‐substitutedphenyl‐1,4‐dihydropyrimidine‐5‐carboxylate)derivatives via microwave irradiations. The reactions were also performed under conventional heating. The reaction times and yields thus obtained of the isolated desired products were compared too, and hence explaining the significance of using microwave irradiations. The structural elucidation of the synthesized moieties was carried out by modern sophisticated spectral techniques. The prepared bis‐heterocycles were screened for their in vitro anti‐microbial activities. Samples that possessed electron‐releasing group on the phenyl ring showed anti‐bacterial activities while those that carry electron‐withdrawing group exhibited anti‐fungal activities.