Abstract
This paper describes bis[3-(triethoxysilyl)propyl]tetrasulfide, which is the first liquid sulfur-transferring agent useful for the conversion of nucleoside phosphite intermediates in the synthesis of the phosphorothioates using a phosphoramidite strategy. This liquid reagent is preferable to existing solid sulfur-transferring agents, because it enables solid-phase synthesis with an automated DNA/RNA synthesizer, while avoiding the risk of accumulation of reagent deposits in the delivery tubes and valves of the synthesizer during sulfurization.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
