Abstract
The title compound, C20H32N5O8P·0.5C4H6O4, is composed of two 9-{2-[bis(pivaloyloxymethoxy)phosphinylmethoxy]ethyl}adenine, commonly known as adefovir dipivoxil (AD), molecules linked to the carboxylic acid groups of succinic acid (SA). The asymmetric unit contains one molecule of AD and half a molecule of SA, which sits on an inversion center. Both adenine units in the two AD molecules make AD–SA N—H⋯O and SA–AD O—H⋯N hydrogen bonds to SA. In addition, the intermolecular AD–AD N—H⋯O—P hydrogen bond serves to stabilize the cocrystal. There is also a π–π stacking interaction [interplanar spacing 3.34 (19) Å] between adjacent inversion-related adenine groups.
Highlights
Data collectionR factor = 0.046; wR factor = 0.143; data-to-parameter ratio = 17.3
The title compound, C20H32N5O8P0.5C4H6O4, is composed of two 9-{2-[bis(pivaloyloxymethoxy)phosphinylmethoxy]ethyl}adenine, commonly known as adefovir dipivoxil (AD), molecules linked to the carboxylic acid groups of succinic acid (SA)
Half a molecule of SA, which sits on an inversion center
Summary
R factor = 0.046; wR factor = 0.143; data-to-parameter ratio = 17.3. The title compound, C20H32N5O8P0.5C4H6O4, is composed of two 9-{2-[bis(pivaloyloxymethoxy)phosphinylmethoxy]ethyl}adenine, commonly known as adefovir dipivoxil (AD), molecules linked to the carboxylic acid groups of succinic acid (SA). The asymmetric unit contains one molecule of AD and half a molecule of SA, which sits on an inversion center. N—H O and SA–AD O—H N hydrogen bonds to SA. The intermolecular AD–AD N—H O—P hydrogen bond serves to stabilize the cocrystal. There is a – stacking interaction [interplanar spacing 3.34 (19) Å].
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