Abstract
As the building blocks of chromatin, histones need to be synthesized efficiently and synchronously with DNA replication. The mRNAs encoding the core histones undergo a distinct 3′‐end formation pathway that results in mature mRNAs ending in a stem loop instead of a polyadenylated tail. Considering that the factors involved in histone 3′‐end processing are well conserved across Eukarya, the absence of some of these components in C. elegans draws the question of how histone 3′ ends are matured in worms. In this issue of The EMBO Journal , Avgousti et al (2012) present an answer that, surprisingly, involves RNAi pathway factors.
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