Birth weight, intrauterine growth restriction and nutritional status in childhood in relation to grip strength in adults: from the 1982 Pelotas (Brazil) birth cohort

Renata Moraes Bielemann,Denise Petrucci Gigante,Bernardo Lessa Horta

doi:10.1016/j.nut.2015.08.014

Renata Moraes Bielemann, Denise Petrucci Gigante + Show 1 more

Open Access

https://doi.org/10.1016/j.nut.2015.08.014

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Abstract

ObjectiveThe aim of this study was to evaluate the association among birth weight, intrauterine growth, and nutritional status in childhood with grip strength in young adults from the 1982 Pelotas (Brazil) birth cohort. MethodsIn 1982, the hospital live births of Pelotas were followed. In 2012, grip strength was evaluated using a hand dynamometer and the best of the six measurements was used. Birth weight was analyzed as z-score for gestational age according to Williams (1982) curve. Weight-for-age, weight-for-length/height, and length/height-for-age at 2 and 4 y were analyzed in z-scores according to 2006 World Health Organization Child Growth Standards. Lean mass at 30 y was included as possible mediator using the g-computation formula. ResultsIn 2012, 3701 (68.1%) individuals were interviewed and 3470 were included in the present analyses. An increase of 1 z-score in birth weight was associated with an increase of 1.5 kg in grip strength in males (95% confidence interval, 1.1–1.9). Positive effect of birth weight on grip strength was found in females. Grip strength was greater in individuals who were born with appropriate size for gestational age and positively associated with weight- and length/height-for-age z-score at 2 and 4 y of age. A positive association between birth weight and grip strength was only partially mediated by adult lean mass (50% and 33% of total effect in males and females), whereas direct effect of weight at 2 y was found only in males. ConclusionsIt is suggested that good nutrition in prenatal and early postnatal life has a positive influence on adult muscle strength. The results from birth weight were suggestive of fetal programming on grip strength measurement.

Highlights

IntroductionLow hand-grip strength is associated with postoperative complications, hospital length of stay, and short-term survival, whereas in epidemiological studies, grip strength is inversely related to all-cause mortality, disability, and RMB conceptualized the study, was responsible for the data collection of grip strength, conducted the statistical analysis, and wrote the manuscript
Grip strength has been associated with several outcomes
Results of the present study demonstrated an important relationship between intrauterine growth and nutritional status at 2 and 4 y and grip strength in young adults belonging to the 1982 Pelotas birth cohort

Summary

Introduction

Low hand-grip strength is associated with postoperative complications, hospital length of stay, and short-term survival, whereas in epidemiological studies, grip strength is inversely related to all-cause mortality, disability, and RMB conceptualized the study, was responsible for the data collection of grip strength, conducted the statistical analysis, and wrote the manuscript. BLH coordinated the last follow-up with participants from the cohort, conducted the statistical analysis, and wrote the manuscript. DPG coordinated the last follow-up with participants from the cohort and wrote the manuscript. This article is based on data from the study Pelotas birth cohort, 1982 conducted by Postgraduate Program in Epidemiology at Universidade Federal de Pelotas.

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