Abstract
Cytomegalovirus (CMV) is a frequent cause of congenital infection in humans in all regions of the world. In contrast to most congenital viral infections, congenital CMV infection and disease have been consistently demonstrated in populations with a high seroprevalence. Three hundred pregnant women were studied prospectively in their 1st, 2nd and 3rd trimester to determine the seroprevalence and seroconversion of CMV in pregnancy. After birth, babies were also tested for anti CMV IgM to determine the rate of birth prevalence. Anti CMV IgG and IgM tests were performed by chemiluminescence methods. All 300 (100%) pregnant women were anti CMV IgG positive and 180 (60%) were subsequently anti CMV IgM positive during different trimesters of pregnancy. Birth prevalence of CMV IgM antibody was 1.3% among babies of anti CMV IgM positive mothers whereas none in CMV IgM negative mothers (OR 1.01, 95% CI .996-1.027).It may be concluded that CMV IgG seroprevalence is high among Bangladeshi pregnant women and the rate of CMV reactivation is also high during pregnancy. Despite protection by maternal immunity a certain percent of babies acquire congenital CMV infection.
Highlights
Cytomegalovirus (CMV) is a common cause of congenital infection in humans in all regions of the world, with an incidence between 0.3% and 2.4% of all live births.[1,2] Infection is more prevalent in underdeveloped countries and among lower socioeconomic groups in developed countries.1Approximately 10 to 15% infants infected with congenital CMV exhibit clinically apparent or symptomatic form of the disease, characterized by petechiae, hepatomegaly, splenomegaly, jaundice, periventricular calcifications, microcephaly, hearing impairment and chorioretinitis
In contrast to most congenital viral infections, congenital CMV infection and disease can occur in children born to women with preexisting immunity to CMV.[6]
Babies were tested for anti CMV IgM to determine the rate of birth prevalence of congenital CMV infection
Summary
Cytomegalovirus (CMV) is a common cause of congenital infection in humans in all regions of the world, with an incidence between 0.3% and 2.4% of all live births.[1,2] Infection is more prevalent in underdeveloped countries and among lower socioeconomic groups in developed countries.1Approximately 10 to 15% infants infected with congenital CMV exhibit clinically apparent or symptomatic form of the disease, characterized by petechiae, hepatomegaly, splenomegaly, jaundice, periventricular calcifications, microcephaly, hearing impairment and chorioretinitis. The remaining 85 to 90% infected infants are asymptomatic at birth, but 15% of them will develop delayed sequel like sensorineural hearing loss, mental retardation, and neurologic deficits.[3,4,5] In contrast to most congenital viral infections, congenital CMV infection and disease can occur in children born to women with preexisting immunity to CMV.[6] The incidence of congenital infection depends on epidemiological characteristics of the population, in particular, the maternal CMV seroprevalence. Protection, is incomplete, and congenital CMV infection may follow recurrent maternal infection.[6,7] Symptomatic congenital CMV infection after a recurrent maternal infection occurs more frequently than previously documented.6-8This study was designed to determine the seroprevalence and seroconversion of CMV in pregnancy as well as the birth prevalence of congenital CMV infection among neonates in a cohort of pregnant women of Bangladesh
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
