Bipolar Radiofrequency Combined with Non-Crosslinked Hyaluronic Acid Mesotherapy: A Protocol for Skin Enhancement

Abstract

Changes associated with aging, such as alterations in epidermal hydration, pigmentation, thickness, and cell renewal, impact skin appearance and may result in laxity, dryness, and uneven skin tone. This case series aimed to evaluate the combined effects of bipolar radiofrequency and non-crosslinked hyaluronic acid mesotherapy on skin appearance, with the goal of achieving synergistic benefits. This retrospective data analysis included subjects aged 33-67 years with facial skin dryness and laxity. Subjects received treatment with a bipolar radiofrequency device on the face, followed immediately by mesotherapy with 2.5 ml of non-crosslinked hyaluronic acid. Photographic documentation and skin analysis were conducted before treatment and 30 days post-treatment. Fourteen subjects with a mean age of 45 years (range 33-67) and presenting with dry, lax facial skin were included. All measured indicators showed significant improvement following the combined radiofrequency and mesotherapy protocol. The combined protocol also correlated with greater improvement in both patient and physician satisfaction, observed immediately after the procedure and at 30 days post-procedure. The treatment was well tolerated, and no adverse events were reported. The combination of bipolar radiofrequency and non-crosslinked hyaluronic acid mesotherapy resulted in significant improvements in skin appearance, firmness, tone, and overall subject satisfaction compared to the baseline condition. The treatments were well received, leading to noticeable enhancements in facial aesthetics. No adverse events were reported, confirming the safety of the protocol.