Abstract
• Two new biphenyl-type neolignans were isolated from Magnolia tripetala. • Tripetalin A was a magnolol-honokiol-type neolignan dimer linked by C-5′‒C-5′′ bond. • Magnoquinone and magnotriol B displayed noteworthy NO inhibitory activity. Tripetalins A ( 1 ) and B ( 2 ), two new biphenyl-type neolignans were obtained from the fruits of Magnolia tripetala , along with four known analogues. The structures of the new compounds were characterized by comprehensive spectroscopic analyses including 1 H, 13 C, and 2D NMR, IR, and HRESIMS data. Tripetalin A ( 1) was the first magnolol-honokiol-type neolignan dimer linked through C-5′‒C5′′ carbon bond. Magnoquinone ( 5 ) and magnotriol B (6) displayed remarkable NO inhibitory activity with IC 50 values of 4.52 ± 0.07 and 2.02 ± 0.03 μ M, respectively.
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