Biphenyl Wrinkled Mesoporous Silica Nanoparticles for pH-Responsive Doxorubicin Drug Delivery.

Jason Lin,Kenneth J Balkus,Chuanqi Peng,Sanjana Ravi,Jie Zheng,A K M Nur Alam Siddiki

doi:10.3390/ma13081998

Jason Lin, Kenneth J Balkus + Show 4 more

Open Access

https://doi.org/10.3390/ma13081998

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Journal: Materials	Publication Date: Apr 24, 2020
Citations: 21	License type: CC BY 4.0

Affiliation: The University of Texas at Dallas

Abstract

Biphenyl wrinkled mesoporous silica nanoparticles with controlled particle size and high surface area were evaluated for the storage and delivery of doxorubicin. The average particle size and surface area were ~70 nm and ~1100 m2/g. The doxorubicin loading efficiency was 38.2 ± 1.5 (w/w)% and the release was pH dependent. The breast cancer cell line, MCF-7 (Michigan Cancer Foundation-7) was used for the in vitro drug release study. The cytotoxicity of doxorubicin-loaded nanoparticles was significantly higher than free doxorubicin. Fluorescence images showed biphenyl wrinkled mesoporous silica (BPWS) uptake by the MCF-7 cells. The biphenyl bridged wrinkled silica nanoparticles appear promising for hydrophobic drug loading and delivery.

Highlights

Nanomedicine [1,2,3,4] and associated drug delivery systems are dependent on both the particle size and drug loading efficiency
We have extended our work with the periodic mesoporous organosilica (PMOs) by incorporating a biphenyl group (Figure 1) and employing this wrinkled mesoporous silica as a drug delivery vehicle
The morphology and the particle size were analyzed by Transmission electron microscopy (TEM)

Summary

Introduction

Nanomedicine [1,2,3,4] and associated drug delivery systems are dependent on both the particle size and drug loading efficiency. The role of porosity is less studied but important for drug loading. Porous materials such as mesoporous silica nanoparticles Kim et al reported ultrasound triggered MCM-41 type mesoporous silica for controlled ibuprofen release [13]. Lu et al demonstrated that mesoporous silica nanoparticles (MSNs) were biocompatible and preferentially accumulate in tumors due to abnormal tumor blood vessels [14]. Lai et al reported MCM-41 using cadmium sulfide as a gatekeeper for the controlled release of vancomycin and adenosine triphosphate [15]. MSNs with phosphorylated lipids have been used for the controlled release of fluorescein [16].

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