Abstract
Three new biphenyl derivatives, bractebiphenyls A–C (1–3), along with five known biphenyl derivatives (4–8) were isolated from the acetone extract of the twigs of Garcinia bracteata. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. The anti-tobacco mosaic virus (anti-TMV) activities of 1–8 were evaluated. Compound 3 showed high anti-TMV activities with inhibition rates of 28.4%, which is close to that of Ningnanmycin (30.2%). Compounds 1–3, 6 and 8 were also tested for their cytotoxicities against five human tumor cell lines (NB4, A549, SHSY5Y, PC3, and MCF7), and 3 showed high cytotoxicities against A549 and PC3 cell with IC50 values of 3.6 and 2.7μM, respectively.
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