Biphasic Variation Over Time in Presenting Features of Patients With COVID-19.

Abstract

* Abbreviations: COVID-19 — : coronavirus disease 2019 MIS-C — : multisystem inflammatory syndrome in children PCR — : polymerase chain reaction SARS-CoV-2 — : severe acute respiratory syndrome coronavirus 2 Current data suggest lower rates of severe coronavirus disease 2019 (COVID-19) in children compared with adults.1,2 Although severe respiratory disease has rarely been described,3 new data suggest the emergence of a COVID-19–related multisystem inflammatory syndrome in children (MIS-C).4,5 Describing the temporal variation of pediatric COVID-19 presentations across the course of a high-prevalence outbreak may help elucidate the epidemiology and biology of these manifestations in children. We conducted a retrospective chart review of children (age ≤20 years) presenting to the New York-Presbyterian Morgan Stanley Children’s Hospital pediatric emergency department from March 13, 2020 (date of first known case), to May 19, 2020, who tested positive for severe acute respiratory syndrome coronavirus … Address correspondence to Nazreen Jamal, MD, Department of Emergency Medicine, Irving Medical Center, Columbia University, CH-N 116, 3959 Broadway, New York, NY 10032. E-mail: nk176{at}columbia.edu