Abstract
Capsaicin (15 or 100 mg/kg, s.c.) produced thermal analgesia in the rat hot plate test (55 °C). Capsaicin (100 mg/kg) also caused a reduction in spinal cord substance P levels. However, the time-course of capsaicin-induced depletion of substance P levels does not correlate with the time-course of thermal analgesia. Also, substance P depletion is biphasic, suggesting that more than one mechanism is involved in capsaicin's ability to reduce substance P levels in the spinal cord.
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