Abstract
Primary cultures of rat hypothalamic neurons in which a 1.1-kb proopiomelanocortin (POMC) mRNA can be detected, were incubated with corticotropin-releasing factor (CRF) for periods of up to 84 h. A cyclic modulation of POMC mRNA concentrations by CRF was noted. A rapid acute inhibition of POMC mRNA levels after 1 h of exposure was followed by a transient stimulation and then by a more prolonged inhibition which reached a nadir after 48 h.
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