Abstract
Hypothalamic but not pituitary immunoreactive β-endorphin (β-E) was significantly reduced (37%) in mice 24 hr following 30 daily doses of nicotine (1200 μg/kg, SC). Hypothalamic β-E returned towards normal levels within 7 days and was observed to rise 50% above normal 14 days after the cessation of nicotine treatment. None of the other neuropeptides measure, substance P, neurotensin, or [met 5]-enkephalin was altered by nicotine treatment. The data suggest that the hypothalamic β-E containing neurons were unable to adapt to nicotine's repeated effects on this system.
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