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Abstract
Pituitary responses to LH-releasing hormone (LH-RH) was studied in normal diestrous rats 2, 4, 6, 9, 14, 24, and 48 hr after injection of estradiol benzoate (EB). A dose of 0.4 µg LH-RH always raised serum LH in the oil-treated rats. The magnitude of the increase varied according to the stage of the estrous cycle, being greatest in proestrus, and smallest between the evening of the day of diestrus I and the morning of the day of diestrus II. Two to 6 hr after pretreatment with EB, injection of this dose of LH-RH failed to induce a significant rise of serum LH. At 9 hr, the same dose of LH-RH did increase serum LH, the magnitude of the response being the same as that found in the oil-treated control rats. By 14–24 hr, EB had augmented the pituitary response to LH-RH. At 48 hr, the magnitude of the rise of serum LH after LH-RH in EB-treated rats was like that found at 24 hr, but this high responsiveness to LH-RH apparently can not be attributed to the EB since a similar responsiveness was seen in the respec...
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