Abstract
We have recently described a 2 column HPLC technique for separating and quantitating the biotransformation products of platinum compounds with the 1,2-diaminocyclohexane (dach) carrier ligand (1). We have also developed a combination HPLC-DNA binding assay which allows quantitation and identification of reactive platinum biotransformation products (Mauldin et al., manuscript submitted for publication). We report here the application of these techniques to the study of two second generation platinum compounds with the dach carrier ligand. These studies have been carried out in tissue culture medium and with cultured L1210 cells.
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