Abstract
Norethisterone is an effective progestogen with a strong endometrial effect. In this study, the biotransformation of norethisterone was performed using a cultivated human intestinal fungal strain (Rhizopus microsporus PT2906) in vitro. Seven metabolites, including two new metabolites (1−2) and five known analogs (3−7), were obtained. The determination of their structures relied on comprehensive spectroscopic data, encompassing 1D NMR, 2D NMR, and HRESIMS. Considering the structures of the norethisterone metabolites, the main biotransformation reactions were revealed to be hydroxylation, lactylation, and dehydration.
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