Abstract

Biotransformation of the isoflavones, 6,7,4′-trimethoxyisoflavone (1) and 5,7,4′-trimethoxyisoflavone (2) by Aspergillus niger was investigated. Compound 1 was transformed to 4′-hydroxy-6,7-dimethoxyisoflavone (3) and 2 to 4′-hydroxy-5,7-dimethoxyisoflavone (4). This suggested that 1 and 2 were demethylated at the C-4′ position with regioselectivity by Aspergillus niger. Copyright © 2006 Society of Chemical Industry

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