Abstract
Biotransformation of α-artemether and dihydroartemisinin (DHA) by Glycyrrhiza glabra (Linn.), Lavandula officinalis (L.), and Panax quinquefolium was investigated. Two metabolites: tetrahydrofuran derivative (3) and a 13-carbon ring-rearranged product (4) were produced from α-artemether (1). DHA (2) provided metabolite 4. The structure of the metabolites were characterized by proton (1H) and carbon (13C) nuclear magnetic resonance (NMR) imaging, fourier transform infrared spectroscopy, and mass spectroscopy. This is the first report that G. glabra and L. officinalis have the capability to biotransform α-artemether, and P. quinquefolium to biotransform DHA. Metabolite 3 is a new compound and metabolite 4 is reported here for the first time from artemisinin derivatives 1 and 2. The presence of acetate function in the derivative 3 and hydroxyl and C-12 deoxo groups in 4 obtained in our study make them interesting synthones for further modification into new clinically potent molecules.
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