Abstract
With the launch of an independent joint venture called Regulus Therapeutics, Isis Pharmaceuticals and Alnylam Pharmaceuticals hope to become a force in the emerging field of therapeutics that target microRNAs. Both firms will contribute intellectual property, technology, and expertise in microRNAs to Regulus, and Alnylam will lay out $10 million in initial funding. Future funding will come equally from Isis and Alnylam. MicroRNAs are small, single-stranded RNAs that are about 20 nucleotides in length. They serve as the gatekeepers for messenger RNAs, regulating mRNAs' ability to relay the instructions for protein production to their intended targets. The roughly 500 microRNAs that have been identified are believed to regulate expression of one-third of all human genes, according to Isis CEO Stanley Crooke. The ubiquity of microRNAs, as well as their ability to broadly modulate disease, has quickly made them an intriguing therapeutic target. Antagonism of microRNA defines a new strategy to ...
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