Biotechnological and Biomedical Applications of Enzymes Involved in the Synthesis of Nucleosides and Nucleotides

Jesús Fernández-Lucas

doi:10.3390/biom11081147

Abstract

Nucleic acid derivatives are involved in cell growth and replication, but they are also particularly important as building blocks for RNA and DNA synthesis [...].

Highlights

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Purine and pyrimidine nucleotides are synthesized through two distinct pathways, de novo and salvage pathways, both depending on 5-phospho-α-D-ribose 1-diphosphate (PRPP) as a key element [1,2]
In the de novo pathway, purine and pyrimidine nucleotides are synthesized from simple molecules such as glycine, glutamine, or aspartate

Summary

Introduction

Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Purine and pyrimidine nucleotides are synthesized through two distinct pathways, de novo and salvage pathways, both depending on 5-phospho-α-D-ribose 1-diphosphate (PRPP) as a key element [1,2]. De novo and salvage pathways, lead to the synthesis of NMPs, which are subsequently phosphorylated to obtain the corresponding nucleoside-5 -di (NDPs) and triphosphates (NTPs).

Results

Conclusion