Biosynthesized silver nanoparticles by Aspergillus terreus NRRL265 for imparting durable antimicrobial finishing to polyester cotton blended fabrics: Statistical optimization, characterization, and antitumor activity evaluation

Abstract

In the current study, the conditions that influence the biosynthesis of silver nanoparticles (AgNPs) by A. terreus NRRL265 cell free filtrate (CFF) were first considered through the “one factor per time” ordinary strategy. At that point a response surface methodology (RSM) was built to study and identify the interdependence between the efficient factors that influence the biosynthesis of AgNPs, utilizing the central composite design (CCD) procedure. Sphere shaped AgNPs in a range between 13 and 49 nm were detected via electron microscopy approaches. The spectroscopy of Fourier Transform Infrared (FTIR) suggested the contribution of peptides as a reducing and capping tool. The viability of AgNPs like an antimicrobial factor was set up by means of its capacity to apply a significant antimicrobial action in opposition to Candida albicans, Bacillus mycoides, and Escherichia coli. Human Caucasian breast adenocarcinoma (MCF7) tumor cells showed a direct dose–response relationship with AgNPs to give an IC50 value of 46.7 μg/mL. AgNP deposition on polyester cotton blended fabrics surface was detected as a thin reliable surface layer through checking scanning electron microscopy (SEM). In spite of the presence of little amounts of silver on the treated fabrics as demonstrated by EDX analysis profile, the fabrics treated with AgNPs were capable to restrain the tested microorganism’s growth.