Biosynthesis of Zinc Oxide Nanoparticles using Cleome gynandra Extract and Evaluation of its Cytotoxic Activities on A549 Cell Line

Abstract

Zinc oxide nanoparticles (ZnONPs) were green synthesised by a simple, rapid, eco-friendly and a cheaper method using Cleome gynandra plant extract. The ZnONPs were characterized using UV- Visible Spectroscopy, FT-IR, XRD, FE-SEM and EDX analysis. The formation of ZnONPs (355 nm) was confirmed by UV visible spectroscopy. The crystalline nature of the nanoparticles was studied by XRD. The presence of different functional groups in the biomolecules was evident from FT-IR spectrum. The morphology of ZnONPs was analysed using SEM and the presence of zinc oxide was confirmed through elemental analysis. They were also analyzed for their biological and antioxidant activities. The green synthesized ZnONPs exhibited a good antibacterial activity against both Gram-negative and Gram-positive bacteria. Furthermore, they exhibited appreciable anticancer activity on the lung (A549) cancer cell lines.