Abstract
1. 1. Labeled uric acid was detected in the renal vesicle of Molgula when 14C-labeled adenine, hypoxanthine or AICA was injected into the whole animal; no labeled uric acid was found when glycine, formate, carbonate or serine was injected. 2. 2. Results obtained with isolated renal vesicles were comparable to those from whole animals. In addition, allopurinol inhibited conversion of hypoxanthine to uric acid in concentrations greater than 10 −5 M, and adenine to uric acid at 10 −6 M in similar preparations. 3. 3. Biosynthesis of uric acid in Molgula is accomplished by interconversion of purines as in man, not by de novo synthesis as in snails, birds and insects. 4. 4. A general scheme for function of stored purines in animals and the possible role of stored uric acid in Molgula are discussed.
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