Abstract
In order to determine whether the somatostatin (SRIF) that can be localized by immunocytochemical means in pancreatic islets is produced in situ, we have investigated this tissue for evidence of SRIF biosynthesis. We have employed the islets of anglerfish, which are free of pancreatic exocrine tissue and consist of nearly 30% SRIF-containing D cells. 1 Results from our initial studies demonstrate that SRIF is synthesized in pancreatic islet tissue and suggest that a larger precursor form may play a role in SRIF biosynthesis.
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