Abstract
Nanobiotechnology is a promising field in the development of safe antibiotics to combat the increasing trend of antibiotic resistance. Nature is a vast reservoir for green materials used in the synthesis of non-toxic and environmentally friendly nano-antibiotics. We present for the first time a facile, green, cost-effective, plant-mediated synthesis of platinum nanoparticles (PtNPs) using the extract of Combretum erythrophyllum (CE) plant leaves. The extract of CE served as both a bio-reductant and a stabilizing agent. The as-synthesized PtNPs were characterized using ultraviolet-visible (UV–Vis) absorption spectroscopy, high-resolution transmission electron microscopy (HR-TEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and dynamic light scattering (DLS) techniques. The HR-TEM image confirmed that the PtNPs are ultrasmall, spherical, and well dispersed with an average particle diameter of 1.04 ± 0.26 nm. The PtNPs showed strong antibacterial activities against pathogenic Gram-positive Staphylococcus epidermidis (ATCC 14990) at a minimum inhibitory concentration (MIC) of 3.125 µg/mL and Gram-negative Klebsiella oxytoca (ATCC 8724) and Klebsiella aerogenes (ATCC 27853) at an MIC value of 1.56 µg/mL. The CE-stabilized PtNPs was mostly effective in Klebsiella species that are causative organisms in nosocomial infections.
Highlights
Nanobiotechnology, an emerging field of nanoscience, has advanced the development of green practices in producing bio-inspired nanoparticles (NPs)
There has been no known research on the use of C. erythrophyllum extract in the green synthesis of platinum nanoparticles (PtNPs) or extracts from the Combretaceae family, as it has been reported for other metal nanoparticles (MNPs) such as silver and gold
The results showed that the Combretum erythrophyllum (CE)-PtNPs exhibited selective antibacterial activity toward specific pathogenic Klebsiella species, which could serve as a means for controlling infectious diseases
Summary
Nanobiotechnology, an emerging field of nanoscience, has advanced the development of green practices in producing bio-inspired nanoparticles (NPs). They can serve as both reducing and stabilizing agents, eliminating the use of hazardous chemical reagents in the synthesis of MNPs [16] These phytochemicals or metabolites can prevent the aggregation of nanoparticles, reduce generic toxicity, and increase their bio-assimilation [4,17,18]. Prior studies have shown that its leaf and extract contain flavonoids, alkaloids, phenolics, carbohydrates, proteins, and essential oils [20,22], which are excellent bio-reductants Despite these excellent properties, there has been no known research on the use of C. erythrophyllum extract in the green synthesis of PtNPs or extracts from the Combretaceae family, as it has been reported for other MNPs such as silver and gold. The results showed that the CE-PtNPs exhibited selective antibacterial activity toward specific pathogenic Klebsiella species, which could serve as a means for controlling infectious diseases
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