Abstract
Green synthesis of silver nanoparticles was carried out using the aqueous extract of Alternanthera sessilis under various experimental conditions. The aqueous extract of Alternanthera sessilis showed significant potential for the quick reduction of silver ions. The synthesized silver nanoparticles were characterized with UV-visible absorption spectrophotometer, XRD, SEM, and FTIR analysis. The average crystallite size as calculated from x-ray diffraction studies and SEM analysis was found to be less than 100 nm. The cytotoxic activity of synthesized nanosilver was carried out against prostate cancer cells (PC3) by MTT assay and found to show significant activity. The present work of biosynthesis of silver nanoparticles using Alternanthera sessilis appears to be cost effective, eco-friendly, and an alternative to conventional method of synthesis.
Highlights
Uncontrolled growth and spread of abnormal cells lead to group of diseases and results in death, which is termed as cancer
We have explored the green synthesis of silver nanoparticles using aqueous extract of Alternanthera sessilis as an alternative to chemical methods of synthesis and studied its antiproliferative effect against prostate cancer cell line (PC3)
The aqueous silver ions were reduced to silver nanoparticles when aqueous extract of Alternanthera sessilis was added
Summary
Uncontrolled growth and spread of abnormal cells lead to group of diseases and results in death, which is termed as cancer. Phytoconstituents like flavonoids, polyphenols possesses astonishing antitumor properties; but there is no proper utilization in terms of cancer drugs due to its solubility nature, less oral intake, and ineffective delivery These can be overcome by the application of nanotechnology (Tabrez et al 2013). Several studies on the cytotoxicity of silver nanoparticles on different cell lines are reported. Silver and gold nanoparticles synthesized using guava and clove extracts showed anticancer efficacy against four different cancer cell lines viz. Synthesized silver sulfide nanoworms showed good cytotoxicity against human cervical cancer cell line (HeLa) is reported by Xing et al 2011. We have explored the green synthesis of silver nanoparticles using aqueous extract of Alternanthera sessilis as an alternative to chemical methods of synthesis and studied its antiproliferative effect against prostate cancer cell line (PC3)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
