Abstract
The AgNPs were synthesized using water-soluble polysaccharides extracted from the Leucaena leucocephala seeds. The UV-visible spectrum of the AgNPs showed a sharp absorption peak at 448 nm. The XRD analysis showed four major peaks of the crystalline AgNPs with planes of a face-centered cubic lattice of silver. The EDS spectrum showed a strong signal peak at ~3 keV. TEM and SEM observations showed the spherical shape of AgNPs with no particle agglomeration, and the size ranged from 8 to 20 nm. AgNPs were highly stable at -14.2 mV by zeta potential measurement. AgNPs showed significant anticancer activity against the cell lines of breast cancer, liver carcinoma, and colon carcinoma with the I C 50 value of 22.5, 12.3, and 8.9 μg mL-1, respectively. AgNPs at 900 μg mL-1 exhibited considerable antifungal activity against ten fungal pathogens. Water-soluble polysaccharide has the ability to synthesize AgNPs keeping strong antitumor, antifungal activities. The AgNPs can slow down spoilage of composite milk samples at different temperatures. In addition, the accuracy of milk-IR-analyses was not affected by different concentrations of AgNPs.
Highlights
Nanoparticles are of great research attention as they have innovative optoelectronic, magnetic, and physicochemical features, affected by their various shape and size details [1]
The chemical analysis of Leucaena leucocephala seeds (LLPs) in this study agreed to some extent with that obtained by the previous report [27]
Silver nanoparticles (AgNPs) were synthesized using polysaccharides extracted from Leucaena leucocephala seeds as a bioreduction and capping agent
Summary
Nanoparticles are of great research attention as they have innovative optoelectronic, magnetic, and physicochemical features, affected by their various shape and size details [1]. The area of food and agriculture research takes benefit of wastes from agroindustrial and agricultural sources to give them an added value, avoiding pollution to the environment by minimizing burning or extreme accumulation [6] In this context, Leucaena leucocephala (Lam.) is a tropical tree that grows in Egypt, perennial thornless, with a height of around 8 m, and belongs to the subfamily Mimosoideae and family Fabaceae with bulk volumes of solid wastes in the form of leaves, ripened fruits, pods, and seeds [7]. Leucaena leucocephala (Lam.) is a tropical tree that grows in Egypt, perennial thornless, with a height of around 8 m, and belongs to the subfamily Mimosoideae and family Fabaceae with bulk volumes of solid wastes in the form of leaves, ripened fruits, pods, and seeds [7] This tree is commonly used as organic fertilizer, timber, gum, fuel, forage, firewood, and raw mass for paper and pharmaceutical industries [8]. The present study is aimed at (1) precipitating the crude polysaccharide of L. leucocephala seeds, (2) characterizing the chemical composition of the crude polysaccharide, (3) using the crude polysaccharide in the preparation of silver nanoparticles, (4) characterizing the synthesized AgNPs using polysaccharides of L. leucocephala seeds, (5) estimating the antitumor and antifungal activities of the biosynthesized AgNPs, (6) evaluating the preservative action of the AgNPs in composite milk samples, and (7) determining the influence of AgNPs on the accuracy of midinfrared milk component testing
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