Abstract
ABSTRACT Green synthesis of selenium nanoparticles (Se NPs) was performed by mixing Hibiscus sabdariffa (roselle plant) leaf extract with the solution of selenious acid (H2SeO3) under continuous stirring conditions resulting the roselle plant secondary metabolites conjugated Se NPs. The existence of functional groups of roselle plant secondary metabolites on the surface of prepared Se NPs was confirmed by Fourier transform infrared spectroscopy (FTIR). The formation of crystalline nanoparticles with anisotropic shape was confirmed by transmission electron microscopy (TEM) images. Furthermore, we also studied anti-oxidative and protective effects of Se NPs in streptozotocin (STZ) induced diabetes rats. These STZ induced diabetic rats were daily exposed to Se NPs or/and insulin treatment and the effect of Se NPs on the factors correlated to oxidative damage in the rat testes were evaluated. The biochemical studies showed that the Se NPs are capable to enhance the serum testosterone reduction caused due to STZ induced diabetes. In addition, Se NPs can significantly reduce the oxidative stress indicators of the testicular tissue such as nitric oxide and lipid peroxidation. However, the treatment of Se NPs on the STZ induced diabetic rats increased the activities of antioxidant enzyme as well as the glutathione content in testicular tissues. Furthermore, microscopic studies revealed that the Se NPs are capable of preventing the histological damage in the testes of STZ induced diabetic rats. Altogether, these results explained the possible effects of Se NPs in attenuating oxidative damage induced by diabetes, especially in the testicular tissue.
Highlights
Selenium (Se) is one among the trace elements neces sary for humans
Green synthesis of selenium nanoparticles (Se NPs) using leaf extract of roselle plant was shown in the current study
The biochemical studies showed that the Se NPs are capable to enhance the serum testosterone reduction caused due to STZ induced diabetes
Summary
Selenium (Se) is one among the trace elements neces sary for humans. Selenium is involved in various processes together with antioxidant defense and immune functions. The deficiency of selenium may cause osseous, cardiac, immune and muscular disturbances in the human body [1,2]. The existence of selenocysteine amino acid in the proteins is mainly responsible for biological functions of sele nium. It was already known that sele nium supplements are protective against wide varieties of harmful factors involving physical factors, such as magnetic fields or heat stress and chemical factors, like drugs causing critical side effects, carcinogens, pesti cides or mycotoxins and heavy metals. It is a complex issue to consider Se as a most effective supplement because of its narrow therapeutic index, Science and Technology of Advanced Materials 21 (2020) 506 applied form and its efficacy that depends on the method and dosage used in the treatment [5,7,8,9,10]
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