Abstract
Endogenous opioid peptides are involved in the genesis or/and control of an epileptic activity in WAG/Rij rats - a genetic model of absence epilepsy. An in situ hybridization study showed that epileptic rats had a significantly higher level of proenkephalin (PENK) mRNA in the striatum and frontal cortex as compared with non-epileptic controls. In contrast to PENK, only age-related changes in PDYN mRNA in the cortex and, to the lesser extent in the striatum were detected in both epileptic and non-epileptic rats. In the hippocampus of epileptic rats, an elevated PDYN mRNA level and no differences in hippocampal PENK mRNA level were found
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