Abstract
The search for intermediates which closely follow uro'gen-III(2) on the biosynthetic pathway to vitamin B12(1) has involved studies with 1-methylbilanes. Four such bilanes, 14C-labelled at the C-1 methyl group, have been synthesised by rational methods and tested as precursors of the corrin macrocycle [e.g.(4)] using an enzyme system from Propionibacterium shermanii. None of the bilanes was incorporated into (4) and this outcome is in full agreement with more recent studies.
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