Abstract
Results obtained from experiments in viva [l-lo] and in vitro [ 1 l] indicate that O-alk-I-enyl glycerol lipids (plasmalogens) are derived from Oalkyl glycerol lipids. However, the question has not been answered about the nature of the immediate precursor of plasmalogens. Desaturation of the alkyl glycerol bond to an alk-1-enyl glycerol bond could possibly occur at any stage after the alkyl glycerol linkage has been formed from dihydroxy acetone phosphate and a long chain alcohol [ 121. The cofiversion in viva of 1-0-(9,10-3H, octadecyl) sn-glycerol 3-phosphoryl (2-14C) ethanolamine and its 2-octadecenoyl derivative respectively into doubly labelled plasmalogens without change of the 3H/‘4C ratio allows us to conclude that alkyl acyl GPE is the direct plasmalogen precursor in the brain. It is further suggested that this conversion represents the main route of degradation of brain alkyl glycerol lipids.
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