Abstract
1. 1. The conversion of C 14-labeled adenine to guanine, which has previously been observed only in intact cells, has been found to occur in soluble extracts of rabbit bone marrow. 2. 2. The yield of guanine was increased 10–20-fold by using adenosine or adenosine 5′-phosphate as precursors in place of free adenine. 3. 3. The synthesis of guanine from adenine riboside or ribotide occurred only in the presence of added DPN. 4. 4. Inosine was an intermediate between adenosine and guanine. Evidence was presented that adenosine 5′-phosphate also passed, in part at least, through a hypoxanthine compound in its conversion to guanine.
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