Biosynthesis of gallic acid fabricated tellurium nanoparticles (GA-Te NPs) for enhanced antibacterial, antioxidant, and cytotoxicity applications

Abstract

The development of antibiotic resistance and the onset of diverse forms of cancer necessitate the utilization of innovative multifunctional biocompatible materials. The synthesis of metal and metalloid nanoparticles through eco-friendly means demonstrates promising potential in therapeutic and diagnostic domains. Among these materials, Tellurium (Te) exhibits exceptional characteristics and finds application in numerous fields; nevertheless, its usage in biological applications has been somewhat limited, primarily due to its inherent toxicity. Furthermore, nanomaterials developed from Te have not garnered adequate research attention. Conversely, nanomaterials fashioned using biomolecules augment their biological efficacy and applicability. Therefore, the present work focuses on synthesizing the tellurium nanoparticles (Te NPs) using the antioxidant molecule gallic acid (GA) and evaluating their biological activity and toxicity for the first time. The study evidenced that GA-Te NPs are spherical and monodispersed, with an average size of 19.74 ± 5.3 nm. XRD analysis confirmed a hexagonal crystalline structure for GA-Te NPs, and FTIR analysis evidenced the capping of GA on Te NPs. GA-Te NPs (MIC: 1.56 μg/mL) strongly reduce the growth and biofilm formation of S. aureus, E. coli, and S. enterica. Additionally, GA-Te NPs at a concentration of 50 μg/mL cause a significant level of toxicity in BT474 breast cancer cells but not in NIH3T3 cells. Unexpectedly, GA-Te NPs at concentrations <250 μg/mL do not cause hemolysis in red blood cells (RBC) Besides, the way of utilizing the lower concentrations of therapeutics could result in ecological safety. Therefore, the study concludes that GA-Te NPs could be used as potential multifunctional agents.