Abstract
An enzyme fraction has been obtained from lactating rabbit mammary particlefree supernatant fraction which synthesizes butyrate from acetyl-CoA by the reversal of β-oxidation. This fraction has been shown to contain acetoacetyl-CoA thiolase, NADH-dependent acetoacetyl-CoA reductase, and crotonyl-CoA hydratase. The reduction of crotonyl-CoA appears to be brought about by the fatty acid synthetase using NADPH or NADH. The two reducing reactions are believed to overcome the thermodynamically unfavorable reaction involved in the condensation of two molecules of acetyl-CoA.
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