Abstract
SummaryBlood and bone marrow cells from normal rabbits and rabbits made anemic with phenylhydrazine were incubated with sodium (2-14C) acetate. The newly-synthesized fatty acids in lipids of both cells and suspending medium were detected by radiochemical gas chromatography. In normal blood, labeled fatty acids were found in the free fatty acid, triclyceride, and phos-pholipid fractions, whereas plasma contained activity only in the free fatty acid fraction. There were no major differences in lipid synthesis by blood from anemic rabbits. Normal bone marrow cells rapidly synthesized fatty acids which were found in free fatty acid, triglyceride, and phospholipid fractions. Similar activities were detected in these 3 lipid fractions of plasma. Incubation of normal bone marrow for 22 hours indicated that labeling of plasma triglycerides and phospholipids had decreased demonstrating reexchange with cellular lipids. There was decreased lipid synthesis in bone marrow cells of anemic rabbits. Labeled fatty acids w...
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