Abstract
Biosynthetic studies of dynemicin A (DNM-A) were carried out by examining the incorporation of singly and doubly 13 C-labeled acetates, [methyl- 13 C]methionine and [ 15 N,2- 13 C]glycine, into DNM-A by cultures of Micromonospora chersina M956-1. The results show that the compound is biosynthesized from two heptaketide chains, which form the bicyclic enediyne core and the anthraquinone moiety, respectively; both are derived from seven head-to-tail coupled acetate units, while the carboxyl group is derived from one carbon of an acetate unit and the O-methyl group from methionine
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