Biosynthesis, in-vitro antioxidant and cytotoxic potential of silver nanoparticles of Abutilon hirtum (Lamp) Sweet

Abstract

The world's leading cause of cancer-related death with most aggressive tumor is hepatocellular carcinoma. Silver nanoparticles have grown in relevance as molecular imaging agents and anticancer activities due to their benefits and versatility. An aqueous extract of Abutilon hirtum was employed in this investigation to produce silver nanoparticles, which showed showed a quick reduction of silver ions, and analysed using UV, Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), Energy-dispersive X-rayanalysis (EDAX), and Scanning electron microscope (SEM) methods. The UV analysis showed 450 nm as the peak of the Plasmon resonance. The scanning electron microscope and x-ray diffraction study determined that the synthesised nanoparticles were spherical in shape with average size range of 15–30 nm. The ATR-FTIR data revealed the functional groups of silver nanoparticles and the biosynthesized nanoparticles were tested for their in-vitro antioxidant and cytotoxic potential against HepG2 cell lines. The synthesized compounds showed significant antioxidant activity in both 2,2-diphenyl-1-picrylhydrazyl (DPPH) and Ferric reducing ability of plasma (FRAP) assays and showed promising cytotoxic activity against HpG2 cell lines by the MTT assay method.