Abstract
The objective of the study was to synthesize gold nanoparticles (Au NPs) using leaf extract of Alternanthera bettzickiana (A. bettzickiana). The biosynthesized Au NPs were characterized using UV–vis spectroscopy, X-ray Diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), Energy dispersive X-ray analysis (EDX), Zeta potential and Transmission electron microscopy (TEM). Morphologically, the Au NPs showed spherical shaped structures. Size distribution of Au NPs calculated using Scherrer’s formula, showed an average size of 80–120 nm. Au NPs were studied for invitro anti-bacterial and cytotoxic activities. Au NPs exhibited significant anti-microbial activity against Bacillu subtilis, Staphylococcus aureus, Salmonella typhi, Pseudomonas aeroginosa, Micrococcus luteus, and Enterobacter aerogenes by agar well diffusion method. The cytotoxic effect of the biogenic synthesized Au NPs against A549 human lung cancer cell lines provided a vigorous evidence of anticancer activity of Au NPs. Further, the toxicity study of the green synthesized Au NPs on Danio rerio (Zebra fish) embryo was evaluated. This study reports that colloidal Au NPs can be synthesized by simple, non-hazardous methods and that bio-synthesized Au NPs have significant therapeutic properties.
Highlights
Metallic nanoparticles have received much attention because of their distinctive properties
Synthesis of Au NPs using leaf extract of A. bettzickiana was preliminarily confirmed by color change from colorless into cherry red color
The present study revealed that Au NPs synthesized using aqueous leaf extract of A. bettzickiana showed has antibacterial property
Summary
Metallic nanoparticles have received much attention because of their distinctive properties. The use of plant extract for the synthesis of nanoparticles could be advantageous over other environmentally benign biological processes by eliminating the elaborate process of maintaining cell cultures [2]. Gold nanoparticles (Au NPs) exhibit unique properties which are of great interest for drug delivery, cellular imaging, diagnostics and therapeutic agents. Synthesis of gold nanoparticles using plant extract is useful because of its reduced environmental, and because it can be used to produce large quantities of nanoparticles. In view of its simplicity, the use of plant extract for reducing metal salts to nanoparticles has attracted considerable attention within the last few decades [5]
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