Abstract
Abstract In the current study, silver nanoparticles (AgNPs) were biosynthesised by microwave irradiation using Azadirachta indica. The formation of AgNPs was confirmed by surface plasmon resonance (SPR) band at 408 nm at UV-visible spectroscopy due to reduction of silver metal into (AgNPs) and further confirmed its particles in nano range. Nine different smart-gel hand wash were prepared by dispersing (AgNPs) in the HPMC and/or Pluronic F-127 polymers. The prepared smart gel hand wash was optimized based on pH, viscosity, spreadability, foamability, clarity. The optimized hand wash (NH5) had pH (6.6 ± 0.33), viscosity (66 ± 0.77, cp), spreadability (24.34 g-cm/s), foamability (100 mL). The optimized hand wash (NH5) showed a superior efficacy against pathogenic organisms in comparison to germ protection based marketed hand wash.
Highlights
Leonard pair of Krauwsetcohfowukatteyrplees(sseaent[i1s0e,pDtice angietniotsni6n.s1t]e);a(diiio)fthsoeaLpeoanndard pair associa module for bra.es;ckH(eoiinv-far)nseaodagnanudphlaaiyinpgrncipgerhrernoaaaenppsedrhpsirawtemhtpaeaisalcythrrahonmtbaiooisaarnymal sapliiznemd otodteallliyn;a(gve) tthheesLkeinonwahridchpacoirucldonbseimstoinregporfoanneytotwmoicorofbaiaml odular Leonar beta-sitosterol, polyphenolic flavonoids [14]
Available Azadirachta indica leaves, authenticated by botanist were selected and rinsed thoroughly many a times with tap water followed by ion free water. 5 g of young leaves was subjected for size reduction in ball mill by adding 100 mL of distilled water aqueous extract was filtered through Whatman No 1 filter paper. 5 mL
The hypothetical mechanism involved in the fabrication of bio silver nanoparticles was the presence of reducing enzymes in neem aqueous extract filtrate that reacts with silver ion of AgNO3, used as scaffolds in the fabrication of Silver nanoparticles, further terpenoids present in azadirachta indica extract acts as a surfactants to stabilized the synthesized AgNPs
Summary
Leonard pair of Krauwsetcohfowukatteyrplees(sseaent[i1s0e,pDtice angietniotsni6n.s1t]e);a(diiio)fthsoeaLpeoanndard pair associa module for bra (see [1, tThheeToererwwwgmraiio]tl,thlwei[grt3sheo,fraoToaprhvlemgehroeaatbrnyherdemadatwosimmfa4aase.1hg.d,eUi5[st7s.ht,5a8ae]g]n).es;ckH(eoiinv-far)nseaodagnanudphlaaiyinpgrncipgerhrernoaaaenppsedrhpsirawtemhtpaeaisalcythrrahonmtbaiooisaarnymal sapliiznemd otodteallliyn (see [11, Lemma 14d.8a]m);a(gve) tthheesLkeinonwahridchpacoirucldonbseimstoinregporfoanneytotwmoicorofbaiaml odular Leonar beta-sitosterol, polyphenolic flavonoids [14]. Azadirachta indica is an evergreen plant native of India and found in Farhat Fatima, Saad M. Alshahrani and Ahmed Alalaiwe, most tropical countries belongs to the family Meliaceae. M. Ahmed et al.: Silver nanoparticle based smart-gel hand wash atoms ranged from 1-100 nm showed predominant robust cytotoxicity to different bacterial cells by interacting with functional group on the bacterial cell membrane and inactivate bacteria. Silver in the presence of water converts to level 1 (Ag+) which could be reactive and binds to protein of the bacteria act as bactericidal [16,17,18,19]
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