Abstract
The incorporation of sodium[2- 14C]acetate and [2- 14C]mevalonic acid into sclareol and digitonon-precipitable sterol (largely β-sitosterol) of Salvia sclarea was studied over intervals of 4 h to 1 week. The incorporation of both precursors into sclareol at all intervals was practically nil; incorporation into sterol and a partially purified acidic triterpene fraction was low but significant, in agreement with previously published work. The incorporation of [2- 14C]mevalonic acid in high percentage into fractions containing the diterpene and sterol, respectively, suggest competition for the labeled substrates by some other (and unknown) terpenoid substances within the plant. A high degree of compartmentalization, restricting access of labeled substrate to the synthetic site, may also account for the low degree of incorporation of [2- 14C]mevalonic acid into sclareol. [ 14C]Sclareol of high specific activity was obtained by exposing plant cuttings to 14CO 2. A differential rate of incorporation of 14CO 2 into sclareol and β-sitosterol was observed; its significance is not known. Possible metabolism of sclareol to other substance within S. sclarea was indicated by a preliminary experiment.
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